Read more Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences.
Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered. Two large-scale pharmacogenomic studies recently screened multiple anticancer drugs on over cell lines.
We compared five different approaches for building predictors of increasing complexity. While testing of drugs on patients in large trials is the only way to assess their clinical efficacy and toxicity, we High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics functional genomics and proteomicstheory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome.
Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated.
We propose to combine these datasets to build and robustly validate genomic predictors of drug response. While testing of drugs on patients in large trials is the only way to assess their clinical efficacy and toxicity, we dramatically lack resources to test the hundreds of drugs currently under development.
Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. We assessed their performance in cross-validation and in two large validation sets, one containing the same cell lines present in the training set and another dataset composed of cell lines that have never been used during the training phase.
Moreover, we observed that response to AAG, an inhibitor of Hsp90, could be efficiently predicted by the expression level of a single gene, NQO1.
Submissions of premature modeling exercises without additional biological insights will not be considered. Try out personalized alert features Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences.
We were able to validate multivariate predictors for three out of the 16 tested drugs, namely irinotecan, PD, and PLX